After graduating from the London School of Economics, Alexia Antsakli Vardinoyanni worked as a fashion writer for the Greek edition of VOGUE interviewing personalities such as Helmut Lang at the Cafe de Flore in Paris, Karl Lagerfeld at his bookshop in Paris and Alber Elbaz at the house of Lanvin.

In 2008 she was appointed coordinator of the destefashioncollection, a yearly project conceived by the Deste Foundation for Contemporary Art, that commissioned artists familiar with the fashion industry to choose five striking designs from that year to interpret visually and/or verbally.

In 2010 she launched through which she continued her encounters with important cultural figures by interviewing and photographing them in their homes or studios.

In 2013 she curated the first exhibition dedicated to design at the Benaki Museum in Athens, entitled 100 chairs in 100 days: A Platonic interpretation, by Martino Gamper.

In 2021 she founded the ARTFLYER foundation to promote innovative ways to connect important cultural figures with an appreciative audience.